UbiVac is a clinical stage immuno-oncology company that offers a pipeline of groundbreaking immunotherapies in preclinical and clinical trials.
Since 2005 the company has been engaged in the research, development and testing of therapeutic immunotherapy strategies to combat cancer and infectious diseases.
UbiVac’s lead product, DPV-001 (DRibble), is a first in class DC-targeted complex vaccine/combination immunotherapy that is “off-the-shelf” and in a National Cancer Institute-supported Phase II clinical trial for the adjuvant treatment of non-small cell lung cancer (NSCLC). Results of this clinical trial document that DPV-001 induces and/or boosts the immune response in every patient who received the vaccine.
The Healthy Immune System
The body’s immune system is designed to preserve normal organisms in a state of health and attack foreign entities that it determines are abnormal. This is generally successful. However, with cancer cells, often these are not seen as abnormal. Therefore, these cells are not—in some cases—targeted for attack and destroyed by the immune system.
In other cases, though, cancer cells are targeted and destroyed. Each person is different and immune systems differ in their reaction to cancer and other abnormal cells. Now many scientists believe that everyone develops cancer in his or her lifetime, but in some the cancer is recognized by the immune system and kept under control, while in others, the cancer is not recognized by the immune system and the cancer is able to spread or metastasize.
UbiVac’s pipeline of technologies and vaccines level the playing field by arming the immune system with the ability to recognize cancer cells. It is thought that many or most patients with cancer fail to recognize their cancer. Since immune recognition of cancer is critical for a patient’s response to checkpoint blockade and many other therapies, UbiVac’s patented technology that can induce or boost immunity against a broad spectrum of cancer targets is considered highly complementary to current and developing drug portfolios across the pharmaceutical and biotechnology industry. Since DPV-001 can induce or boost immunity against a large number of cancer targets, this makes it much harder for cancer cells to downregulate all of the targets so they can escape immune detection and elimination.
Immunotherapy can help target cancer cells in various ways. One way is by inducing B cells to make antibodies that can turn off tumor cell function, destroy the cancer itself, or prevent metastases. Another is by inducing T cells that can recognize and destroy cancer cells. A third way is by inducing innate elements of the immune system, including NK cells, to destroy cancer. UbiVac’s DRibble technology can enable all three of these mechanisms of immune-mediated destruction of cancer cells.
For additional information about immunotherapy please follow this link to the Society for Immunotherapy of Cancer.